解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIM:Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant. Several studies have shown that beta asarone causes liver and cardiac damages but the reproductive toxicity is not well understood. The present study was initiated to investigate whether beta asarone ha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.08.021
更新日期:2017-03-15 00:00:00
abstract:AIMS:Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Lesional apoptotic cells and necrotic core forma...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.02.003
更新日期:2017-03-15 00:00:00
abstract:AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.12.015
更新日期:2017-03-01 00:00:00
abstract:AIMS:Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.01.008
更新日期:2017-03-01 00:00:00
abstract:AIMS:Aberrant expression of miRNAs exert the critical roles in carcinogenesis, including cervical cancer. Recent study corroborated the down-regulation of miR424-5p in uterine cervix adenocarcinoma. This research aimed to investigate the function and underlying mechanisms of miR424-5p in cervical cancer cell growth. M...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.01.006
更新日期:2017-02-15 00:00:00
abstract:AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.01.005
更新日期:2017-02-15 00:00:00
abstract::Cancer cachexia characterized by a chronic wasting syndrome, involves skeletal muscle loss and adipose tissue loss and resistance to conventional nutritional support. Cachexia is responsible for the reduction in quality and length of life of cancer patients. It also decreases the muscle strength of the patients. The p...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.11.033
更新日期:2017-02-01 00:00:00
abstract:AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.12.002
更新日期:2017-02-01 00:00:00
abstract:AIMS:Pulmonary hypertension (PH) is a proliferative disorder characterized by enhanced proliferation and suppressed apoptosis of intrapulmonary vascular smooth muscle cells. Recently, network-based bioinformatics have identified let-7 family, a tumor suppressive microRNA, regulate multiple interacting targets relevant ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.11.020
更新日期:2017-02-01 00:00:00
abstract:AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.11.002
更新日期:2017-01-01 00:00:00
abstract:AIMS:Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found. Levosimendan demonstrated neuroprotective effects and reduced mortality...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.11.006
更新日期:2017-01-01 00:00:00
abstract::The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.11.005
更新日期:2016-12-15 00:00:00
abstract:AIM:Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS:Th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.10.026
更新日期:2016-12-15 00:00:00
abstract:AIMS:It has been shown that exposure to extremely-low frequency (˂300Hz) oscillating electromagnetic field (EMF) can affect gene expression. The effects of different exposure patterns of 50-Hz EMF and co-treatment of EMF plus cisplatin (CDDP) on mRNA levels of seven genes involved in DNA repair pathways (GADD45A, XRCC1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.10.006
更新日期:2016-12-01 00:00:00
abstract:AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.08.029
更新日期:2016-11-15 00:00:00
abstract:AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.09.001
更新日期:2016-11-01 00:00:00
abstract::Melanin in the skin determines the skin color, and decreased melanin causes many hypopigmentation disorders and increased damage to skin by ultraviolet B (UVB) light irradiation. Here, we stimulate melanogenesis in B16F10 melanoma cells by using specific frequencies of ELF-EMFs. In this study, we focus on the melanoge...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.08.015
更新日期:2016-10-01 00:00:00
abstract:AIMS:C-reactive protein (CRP) is an inflammatory cytokine that has been shown to be an independent predictor of future atherothrombotic events. Hyperactivity of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by the endothelium, is linked with cardiovascular disease development and progression. ET-1 is s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.12.030
更新日期:2016-08-15 00:00:00
abstract::Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.01.016
更新日期:2016-08-15 00:00:00
abstract:AIM:The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. MAIN METHODS:The data obtained from MTT assays, performed on cells treated with protolichester...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.023
更新日期:2016-08-01 00:00:00
abstract::The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.06.024
更新日期:2016-08-01 00:00:00
abstract:AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.045
更新日期:2016-07-15 00:00:00
abstract::The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.043
更新日期:2016-07-15 00:00:00
abstract:AIMS:Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.008
更新日期:2016-07-15 00:00:00
abstract:AIMS:To investigate the roles of neutrophil alkaline phosphatase (NAP) in the migration, reactive oxygen species (ROS) generation and apoptosis of neutrophils. MAIN METHODS:NAP was overexpressed in neutrophil-like differentiated HL-60 cells via transfecting coding sequence of NAP by lentivirus. NAP overexpression in H...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.005
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND:Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in adipose tissue, disturbing its metabolism and the balance of adipokines, related to obesity. The altering secretion pattern of adipokines from the adipose tissue and the increasing mechanical load in weight-bearing joint...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.010
更新日期:2016-07-15 00:00:00
abstract:AIMS:We investigated the implication of PKA and Epac proteins in the endothelium-independent vasorelaxant effects of cyclic AMP (cAMP). MAIN METHODS:Cytosolic Ca(2+) concentration ([Ca(2+)]c) was measured by fura-2 imaging in rat aortic smooth muscle cells (RASMC). Contraction-relaxation experiments were performed in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.03.059
更新日期:2016-06-15 00:00:00
abstract:AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.023
更新日期:2016-06-15 00:00:00
abstract:AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.035
更新日期:2016-06-15 00:00:00
abstract:AIMS:The aim of this study was to find out a mesenchymal stem cells (MSCs) source from human dental tissues of the same donor (follicle, papilla and pulp), which exhibits higher neurogenic differentiation potential in vitro. MAIN METHODS:MSCs were isolated from dental tissues (follicle, papilla and pulp) by digestion ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.026
更新日期:2016-06-01 00:00:00
abstract:AIM:Membranous nephropathy remains the most common form of the nephrotic syndrome in adults. The combination therapy of steroid and cyclophosphamide has routinely been used. Although satisfactory therapeutic efficacy can be achieved, its side effect on reproductive system has been a concern. Mizoribine is an imidazole ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.012
更新日期:2016-06-01 00:00:00
abstract:AIMS:Neurocardiac dysfunction is a life-threatening systemic consequence of subarachnoid hemorrhage (SAH) that contributes to triggering delayed cerebral ischemia (DCI). This study aimed to determine the impact of dobutamine cardiac support during isoflurane postconditioning on post-SAH DCI. MAIN METHODS:Male C57BL/6 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.020
更新日期:2016-05-15 00:00:00
abstract::Diabetic retinopathy, a common secondary complication of diabetes mellitus, involves extensive damage to the retinal microvasculature. Retina, being a susceptible target, is highly prone to hyperglycemia-induced molecular damages. PPAR receptor, chiefly gamma subtype, mediates numerous responses related to glucose met...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.03.054
更新日期:2016-05-15 00:00:00
abstract:UNLABELLED:The mechanisms by which exercise affects atherosclerotic plaque stability remain incompletely understood. We evaluated the effects of two training protocols on both atherosclerotic plaque structure and the signaling pathways involved in plaque rupture. METHODS:Male low-density lipoprotein (LDL) receptor kno...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.04.007
更新日期:2016-05-15 00:00:00
abstract:AIM:The present study aimed to understand the relationship between pharmacological activation of mGlu4 receptors and regulation of its gene in the hippocampus. MAIN METHODS:The expression level of the GRM4 gene, encoding mGluR4 receptors, was studied in the hippocampus and frontal cortex of rats after pharmacological ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.03.033
更新日期:2016-05-15 00:00:00
abstract:AIM:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and thus, the ability of antidiabetic drugs to ameliorate renal microvascular disease may be as important as their ability to control blood glucose. Therefore, we investigated the reno-protective effect of the antidiabetic drugs, Sitagliptin a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.03.043
更新日期:2016-05-15 00:00:00
abstract::Depression is a leading cause of disability worldwide. However, the biological and molecular mechanisms underlying this disease remain unclear. Stress, a disposing factor in the development of depression, leads to hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoids release. Glucocorticoids at phys...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.03.022
更新日期:2016-05-01 00:00:00
abstract::It has been shown that the antagonism of glutamate receptors activity was able inhibit proliferation and induce apoptosis in several neuronal and non-neuronal cancer cell lines. In addition, it has been shown that glutamate might facilitate the spread and growth of leukemia T cells through interactions with AMPA recep...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.03.051
更新日期:2016-05-01 00:00:00
abstract:AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.03.053
更新日期:2016-05-01 00:00:00
abstract:AIMS:Proton Nuclear Magnetic Resonance (NMR) based metabolomics analysis is extensively used to explore the metabolic profiling of biofluids. This approach was used for the analysis of metabolites in serum of patients with major types of muscular dystrophy in early phase of the disease. MATERIAL AND METHODS:Proton NMR...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.01.032
更新日期:2016-04-15 00:00:00